Property Building in Hampton Inn & Suites - Saint Louis South Interstate 55
Hampton Inn

Hampton Inn & Suites - Saint Louis South Interstate 55

Hotel Highlights

Welcome to the Hampton Inn & Suites - Saint Louis South Interstate 55, your home away from home just a stone's throw from the vibrant charm of East Saint Louis! Nestled at 4200 Midamerica Lane, our hotel is the perfect launchpad for adventure seekers wanting to explore all that the region has to offer. Whether you're in town for business or leisure, enjoy our cozy accommodations starting at just $110 per night—where comfort meets convenience!

Bedroom, TV/Entertainment Center in Hampton Inn & Suites - Saint Louis South Interstate 55
Property Building in Hampton Inn & Suites - Saint Louis South Interstate 55

Rooms

Double Room with Two Double Beds - Disability Access/Non-Smoking in Hampton Inn & Suites - Saint Louis South Interstate 55

Show 5 photos

2 Queen Size Beds

/

300 sqft

Room - 2 Double/2 Queen, Accessible

Private Bathroom

Air conditioning

Free toiletries

"Experience comfort and convenience in our spacious Quadruple Double Room, featuring two queen size beds, perfect for accommodating 4 adults and 3 children. Relax in the ample 301 sqft room with air conditioning, private bathroom, and enjoy complimentary toiletries for a rejuvenating stay." (230 symbols)

King Studio Suite with Whirlpool - Non-Smoking in Hampton Inn & Suites - Saint Louis South Interstate 55

1 King Size Bed

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300 sqft

Studio

Spa tub

Microwave

Flat-screen TV

Refrigerator

Indulge in our King Studio - Non-Smoking room, perfect for a group of 3 adults and 2 children. Enjoy the spaciousness of 301 sqft and be treated to the comfort of a King size bed, private bathroom, air conditioning, and free toiletries.

Show 9 photos

1 King Size Bed

1 Sofa Bed

Studio, Accessible

Free wifi

Microwave

Flat-screen TV

Refrigerator

Discover More

Get ready to kick off your day with a delicious complimentary breakfast that fuels your wanderlust and energizes your adventures. After breakfast, take a leisurely dip in our indoor swimming pool or work up a sweat in our fully equipped fitness center. Free Wi-Fi will keep you connected while on the go, plus we provide free parking for all our guests. Located just 14.6mi from the bustle of city center, you can easily venture into the heart of St. Louis and then retreat to the tranquil surroundings of your hotel.

Property Building in Hampton Inn & Suites - Saint Louis South Interstate 55
Bedroom, Bathroom in Hampton Inn & Suites - Saint Louis South Interstate 55

Experience the Best

We pride ourselves on our friendly service, boasting 579 rave reviews to prove it! With features like a 24-hour front desk, business center, meeting facilities, and accessible amenities, we cater to all types of travelers. So whether you’re traveling solo, with family, or for a special event, our non-smoking rooms ensure a refreshing stay. Unwind in comfort at the Hampton Inn & Suites, where a memorable experience awaits!

Photo of the whole room, Bed in Hampton Inn & Suites - Saint Louis South Interstate 55
Bed in Hampton Inn & Suites - Saint Louis South Interstate 55

Plan Your Stay

After a day of exploring the stunning urban sights of St. Louis or enjoying the delights of East St. Louis, it’s time to unwind at the Hampton Inn & Suites. Our indoor swimming pool provides the perfect escape for families or couples looking to relax and rejuvenate. Dive into the inviting waters, splash around with the kids, or float your cares away – no matter the season, there's always a chance to soak up the fun. Plus, if you’re feeling like a workout, our fully equipped fitness center stands ready for you to burn off that extra slice of pie from breakfast.

Restaurant/places to eat, Supermarket/Shops in Hampton Inn & Suites - Saint Louis South Interstate 55
Bedroom, TV/Entertainment Center in Hampton Inn & Suites - Saint Louis South Interstate 55

Amenities

Free parking

Indoor swimming pool

Business center

Free wifi

Fitness center

Meeting/Banquet facilities

Air conditioning

Parking On Site

Bathroom in Hampton Inn & Suites - Saint Louis South Interstate 55
Restaurant/places to eat, Supermarket/Shops in Hampton Inn & Suites - Saint Louis South Interstate 55

Pool

Indoor

All season,

Pool view, Swimming Pool in Hampton Inn & Suites - Saint Louis South Interstate 55
Bedroom, Bed in Hampton Inn & Suites - Saint Louis South Interstate 55
Property Building in Hampton Inn & Suites - Saint Louis South Interstate 55
I loved everything about the property, but what stood out the most was the cleanliness. The beds are firm, but the linens were nice, comfy, and clean. The room had some of the cleanest I have ever seen in a hotel. The staff was very professional, and I loved the lighting in the room we stayed in(a double queen). The thermostat being on the wall was nice as well because you don’t freeze as easily as you do with just a unit with a knob like most hotels. I’ve read through reviews and that helped me make my decision to stay here with my family, and we were not disappointed. They seem to really respond to any concerns. I appreciate professionalism and integrity. We would definitely stay here again.

Tiffany

Loved the quiet location. All the staff at the front desk and breakfast were super friendly. Our daughter loved the nightly cookies and milk.The three cleaning staff I spoke with were friendly and respectful, with the exception of one. This one was upset that I brought wet towels down for exchange vs leaving them to dampen the hallway outside our door. Acted as if she would get a disease if she took them from me.

Vanessa

The breakfast spread every morning was great and had a variety. The staff were all helpful and pleasant. The pool was warm and good size and stayed open till 10pm. They serve cookies every night from 8 to 9pm which was great for the kids. The location was 20 to 25 min to everything we wanted to do, which wasn't to bad of a drive.

Richelle

The staff was very friendly and efficient. The room was clean and nice. The breakfast was good and it was different for every day of our 5 day stay The staff called us when my husband left his glasses in our room. We were able to get them before our flight left We loved the nightly "Cookie Lady" she was a joy!!

William

Pillows were so comfortable. Wish I could buy some for my personal use. Staff was always very friendly. Breakfast was good, except my husband would have liked doughnuts or sweet rolls instead of muffins. Rooms were clean, beds very comfortable.

Patricia

I loved everything about the property, but what stood out the most was the cleanliness. The beds are firm, but the linens were nice, comfy, and clean. The room had some of the cleanest I have ever seen in a hotel. The staff was very professional, and I loved the lighting in the room we stayed in(a double queen). The thermostat being on the wall was nice as well because you don’t freeze as easily as you do with just a unit with a knob like most hotels. I’ve read through reviews and that helped me make my decision to stay here with my family, and we were not disappointed. They seem to really respond to any concerns. I appreciate professionalism and integrity. We would definitely stay here again.

Tiffany

Loved the quiet location. All the staff at the front desk and breakfast were super friendly. Our daughter loved the nightly cookies and milk.The three cleaning staff I spoke with were friendly and respectful, with the exception of one. This one was upset that I brought wet towels down for exchange vs leaving them to dampen the hallway outside our door. Acted as if she would get a disease if she took them from me.

Vanessa

The breakfast spread every morning was great and had a variety. The staff were all helpful and pleasant. The pool was warm and good size and stayed open till 10pm. They serve cookies every night from 8 to 9pm which was great for the kids. The location was 20 to 25 min to everything we wanted to do, which wasn't to bad of a drive.

Richelle

The staff was very friendly and efficient. The room was clean and nice. The breakfast was good and it was different for every day of our 5 day stay The staff called us when my husband left his glasses in our room. We were able to get them before our flight left We loved the nightly "Cookie Lady" she was a joy!!

William

Pillows were so comfortable. Wish I could buy some for my personal use. Staff was always very friendly. Breakfast was good, except my husband would have liked doughnuts or sweet rolls instead of muffins. Rooms were clean, beds very comfortable.

Patricia

I loved everything about the property, but what stood out the most was the cleanliness. The beds are firm, but the linens were nice, comfy, and clean. The room had some of the cleanest I have ever seen in a hotel. The staff was very professional, and I loved the lighting in the room we stayed in(a double queen). The thermostat being on the wall was nice as well because you don’t freeze as easily as you do with just a unit with a knob like most hotels. I’ve read through reviews and that helped me make my decision to stay here with my family, and we were not disappointed. They seem to really respond to any concerns. I appreciate professionalism and integrity. We would definitely stay here again.

Tiffany

Loved the quiet location. All the staff at the front desk and breakfast were super friendly. Our daughter loved the nightly cookies and milk.The three cleaning staff I spoke with were friendly and respectful, with the exception of one. This one was upset that I brought wet towels down for exchange vs leaving them to dampen the hallway outside our door. Acted as if she would get a disease if she took them from me.

Vanessa

The breakfast spread every morning was great and had a variety. The staff were all helpful and pleasant. The pool was warm and good size and stayed open till 10pm. They serve cookies every night from 8 to 9pm which was great for the kids. The location was 20 to 25 min to everything we wanted to do, which wasn't to bad of a drive.

Richelle

The staff was very friendly and efficient. The room was clean and nice. The breakfast was good and it was different for every day of our 5 day stay The staff called us when my husband left his glasses in our room. We were able to get them before our flight left We loved the nightly "Cookie Lady" she was a joy!!

William

Pillows were so comfortable. Wish I could buy some for my personal use. Staff was always very friendly. Breakfast was good, except my husband would have liked doughnuts or sweet rolls instead of muffins. Rooms were clean, beds very comfortable.

Patricia

Location

4200 Midamerica Lane, Saint Louis, 63129, Missouri, United States

Reservations:

+1-833-728-2041

or
Hampton Inn & Suites - Saint Louis South Interstate 55